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Tyrphostin AG 879
CAS No. 148741-30-4
Tyrphostin AG 879 ( Val-boroPro (mesylate) | PT100 (mesylate) )
产品货号. M17320 CAS No. 148741-30-4
Tyrphostin AG 879 有效抑制 HER2/ErbB2 (IC50: 1 μM)，对 ErbB2 的选择性比 EGFR 和 PDGFR 高 100 倍和 500 倍。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥348 | 有现货 |
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| 10MG | ￥551 | 有现货 |
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| 25MG | ￥1280 | 有现货 |
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| 50MG | ￥2130 | 有现货 |
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| 100MG | ￥3645 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Tyrphostin AG 879
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Tyrphostin AG 879 有效抑制 HER2/ErbB2 (IC50: 1 μM)，对 ErbB2 的选择性比 EGFR 和 PDGFR 高 100 倍和 500 倍。
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产品描述AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.
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体外实验Cell Proliferation Assay Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Significantly and dose dependently decreased cell proliferation in all the cell lines.Apoptosis Analysis Cell Line:HL-60, U-937, PC-3, HTB-82, HTB-114, TE-671, HTB-115 and HTB-88 cells Concentration:0.5 μM, 5 μM, 20 μM and 50 μM Incubation Time:48 hours Result:Induced a dose-dependent increase in apoptosis.
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体内实验——
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同义词Val-boroPro (mesylate) | PT100 (mesylate)
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通路Angiogenesis
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靶点ALK
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受体EGFR| HER2-Neu| PDGFR| Trk
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研究领域Cancer
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适应症——
化学信息
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CAS Number148741-30-4
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分子量316.46
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分子式C18H24N2OS
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 30 mg/mL. 94.80 mM
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SMILESOc1c(C(C)(C)C)cc(/C=C(\C#N)/C(=S)N)cc1C(C)(C)C
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化学全称2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856.
