Tyrphostin AG 879 ( Val-boroPro (mesylate); PT100 (mesylate) )

产品货号. M17320 CAS No. 148741-30-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Tyrphostin AG 879
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
产品描述

AG-879 is a tyrphostin compound that inhibits nerve growth factor-dependent TrkA tyrosine phosphorylation in PC-12 cells, HER2-ErbB2 kinase in several breast and ovarian cancer cell lines, and the VEGF receptor FLK1. It decreases cellular proliferation in human muscular sarcoma cell lines.
同义词

Val-boroPro (mesylate); PT100 (mesylate)
通路

Angiogenesis
靶点

ALK
受体

EGFR; HER2-Neu; PDGFR; Trk
研究领域

Cancer
适应症

——

CAS Number

148741-30-4
分子量

316.46
分子式

C18H24N2OS
纯度

98%
溶解度

DMSO : ≥ 30 mg/mL. 94.80 mM
SMILES

Oc1c(C(C)(C)C)cc(/C=C(\C#N)/C(=S)N)cc1C(C)(C)C
化学全称

2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)-

1. Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856.

计算器

产品手册

关联产品

WY-135

WY-135 (WY135) is a novel potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
Blu-782

Blu-782 is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM).
AZD3463

AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.